Placebo cohorts of RRMS trials 1996–2013 (n = 21).

RRMS = Relapsing-remitting Multiple Sclerosis, Pub.Year = Year of Publication, N = patients in placebo cohort, Age = mean Age at baseline, Relapse Rate = annualized pre-study relapse rate, EDSS = mean EDSS at baseline, Gd = Gd-enhancing lesion, T2 = T2 hyper intense lesion, Diag. Criteria = Diagnostic Criteria (Poser, 2001 = McDonald 2001, 2005 = McDonald 2005), Summary data are presented as median, Comparison of phase2 and 3 baseline data with Mann-Whitney test except for diagnostic criteria (chi square test), * = p<0.05 Placebo cohorts of RRMS trials 1996–2013 (n = 21).