Data from: Complex Causal Association between Genetically Predicted 731 Immunocyte Phenotype and Acute Respiratory Distress Syndrome: A bidirectional Two-sample Mendelian Randomization Analysis

This study probed the causal interconnections between 731 immunocyte phenotypes and acute respiratory distress syndrome (ARDS) via Mendelian randomization methodologies. The MR analysis discerned six immune cell phenotypes with statistically significant positive correlations, and four with protective associations, in relation to ARDS, with parallel associations observed in pediatric ARDS (PARDS). The accompanying datasets encompass the ancillary results, including scatter plots, sensitivity analyses (leave-one-out), and funnel plots pertinent to each immunocyte phenotype linked to ARDS or PARDS. These findings collectively elucidate the intricate immune pathways involved in ARDS pathogenesis, thereby offering insights for potential therapeutic avenues.

本研究通过孟德尔随机化方法探究了731种免疫细胞表型与急性呼吸窘迫综合征（ARDS）之间的因果联系。孟德尔随机化分析揭示了六种具有统计学上显著正相关性的免疫细胞表型，以及四种具有保护性关联的表型，与ARDS相关，并在儿童急性呼吸窘迫综合征（PARDS）中观察到平行关联。伴随的数据集包含了辅助结果，包括散点图、敏感性分析（留一法）和针对与ARDS或PARDS相关的每种免疫细胞表型的漏斗图。这些发现共同阐明了ARDS发病机制中涉及的复杂免疫途径，从而为潜在的疗愈途径提供了洞见。