Cyclic sulfones from double conjugate addition of Rongalite
收藏Taylor & Francis Group2023-06-29 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/Cyclic_sulfones_from_double_conjugate_addition_of_Rongalite/23494869
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资源简介：
Cyclic sulfones are obtained in up to 92% yield by double conjugate addition of Rongalite (sodium hydroxymethyl sulfinate) to dienones. The major product in each case is the kinetic <i>trans</i>-isomer of the 3,5-disubstituted ketosulfone. Eleven examples, including aryl and alkyl substituted substrates, are reported. The advantages of the method are its experimental simplicity, tolerance for both protic and oxidation-sensitive functional groups, and sterically challenging substrates. The work also significantly expands the scope of Rongalite as a conjugate nucleophile.
提供机构：
Prana, Jazmine; Muro, Antonia; Zong, Hao; Brenya, Janet; Michel, Rudolph; Bebbington, Magnus W. P.; Rubin, Elana; Goga, Melina
创建时间：
2023-06-10
