Stromal niche inflammation mediated by IL-1 signaling is a targetable driver of hematopoietic aging

NIAID Data Ecosystem2026-03-14 收录

造血衰老机制

炎症信号靶点

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE169162 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2023-02-02

Aging of the Microenvironment Influences Clonality in Hematopoiesis

造血衰老机制

白血病克隆演化

The mechanisms of the age-associated exponential increase in the incidence of leukemia are not known in detail. Leukemia as well as aging are initiated and regulated in multi-factorial fashion by cell

NIAID Data Ecosystem80

Myeloid Skewing in Aging Bone Marrow Depends on Long-lived Plasma Cell Accumulation

造血衰老机制

长寿命浆细胞功能

Aging results in a reduction in B lymphopoiesis and an increase in myelopoiesis in mice and humans. We investigated how cellular changes in the aging hematopoietic microenvironment contribute to these

NIAID Data Ecosystem60

Using bone marrow stromal cells as micro-environmental sensors identifies IL-6 and TGFa signalling as regulators of declining erythropoiesis and lymphopoiesis during hematopoietic ageing. Using bone marrow stromal cells as micro-environmental sensors identifies IL-6 and TGFa signalling as regulators of declining erythropoiesis and lymphopoiesis during hematopoietic ageing

造血衰老机制

骨髓微环境信号通路

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem30

Stromal inflammation is a targetable driver of hematopoietic aging [droplet-based scRNAseq]

造血衰老机制

骨髓微环境

To investigate global changes in the structure of the bone marrow niche with age, we performed droplet-based scRNAseq (10X Genomics) of unfractionated endosteal and central marrow stromal cells (Ter11

NIAID Data Ecosystem60

Distinct roles for NF-?B in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging

造血衰老机制

NF-κB信号通路

Hematopoietic aging is characterized by chronic inflammation associated with myeloid bias, hematopoietic stem cell (HSC) accumulation, and functional HSC impairment. Yet it remains unclear how inflamm

NIAID Data Ecosystem40

Stromal niche inflammation mediated by IL-1 signaling is a targetable driver of hematopoietic aging

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