Structure of the human mitochondrial pyruvate carrier inhibited by a UK5099-derivative

Structure of the human mitochondrial pyruvate carrier inhibited by a UK5099-derivative Descriptor: (2E)-2-cyano-3-[(5M)-5-(2-nitrophenyl)furan-2-yl]prop-2-enoic acid, Mitochondrial pyruvate carrier 1-like protein, Mitochondrial pyruvate carrier 2, ... Authors: Sichrovsky, M, Lacabanne, D, Ruprecht, J.J, Rana, J.J, Stanik, K, Dionysopoulou, M, Sowton, A.P, King, M.S, Jones, S, Cooper, L, Hardwick, S.W, Paris, G, Chirgadze, D.Y, Ding, S, Fearnley, I.M.F, Palmer, S, Pardon, E, Steyaert, J, Leone, V, Forrest, L.R, Tavoulari, S, Kunji, E.R.S. Deposit date: 2024-08-19 Release date: 2025-05-07 Last modified: 2026-04-15 Method: ELECTRON MICROSCOPY (3.65 Å) Cite: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier. Sci Adv, 11, 2025