Pathology report in GATA6 Heterozygous mouse ovaries.

A total of 47 GATA6 (+/−) mice were analyzed for ovarian phenotype. The majority of mice were analyzed between the age of 12–18 months. Ovarian tissues were harvested and subjected to histological analysis. More than 20 wildtype littermates were also analyzed as controls. The 47 GATA6 (+/−) mice exhibited the presence of ovarian inclusion cysts in 12 (26%), surface papillomatosis in 5 (11%), and hyperplasia of surface epithelial cells in 6 (13%). Only one in the 20 wildtype mice of same age range showed mild surface papillomatosis.