Comparison of the Effect of Mutations in NarK2 to Mutations in the Comparable Amino Acids in Other Nitrate/Nitrite Porters.

Mutations created in the M. tuberculosis narK2 are compared to mutations in the comparable amino acid of other nitrate transporters. ‘Inactive’ indicates a protein with no activity, while ‘inhibit’ is defined as reduced activity. ‘No effect’ refers to wild type levels of activity. In examples where more than one mutation was made two results may be listed.aAssimilatory NrtA of Aspergillus nidulans[27], [41].bRespiratory NarU of E. coli[39].cRespiratory NarK of Paracoccus pantotrophus[42].