Highly proliferating NK cells in responce to SARS-CoV-2 peptides

Natural killer (NK) cells play a pivotal role in the immune response against viral infections, including SARS-CoV-2. However, the comprehension of memory NK cell responses to SARS-CoV-2 remains limited. To address these challenges, we investigated the memory response of NK cells to SARS-CoV-2 peptides, presented by autologous cells. Investigation of highly proliferating NK cells demonstrated the formation of distinct clusters depending on the SARS-CoV-2 peptides supplementation and donor group. RNA sequencing revealed differential gene expression patterns, highlighting metabolism, protein transport, and immune response genes. These findings provide detailed insights into NK cell memory responses to SARS-CoV-2 peptides, indicating potential mechanisms underlying NK cell activation and antiviral immunity.