A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1, version 3

The Stockholm Sleepy Brain Study I is a functional brain imaging study of 48 younger (20-30 years) and 36 older (65-75 years) healthy participants, with magnetic resonance imaging after normal sleep and partial sleep deprivation in a crossover design. We performed experiments investigating emotional mimicry, empathy for pain, and cognitive reappraisal, as well as resting state functional magnetic resonance imaging (fMRI). We also acquired T1- and T2-weighted structural images and diffusion tensor images (DTI). On the night before imaging, participants were monitored with ambulatory polysomnography and were instructed to sleep either as usual or only three hours. Participants came to the scanner the following evening. Besides MRI scanning, participants underwent behavioral tests and contributed blood samples, which have been stored in a biobank and used for DNA analyses. Participants also completed a variety of self-report measures. The resulting multimodal dataset may be useful for hypothesis generation or independent validation of effects of sleep deprivation and aging, as well as investigation of cross-sectional associations between the different outcomes.
A full description of study design and procedures is available at: https://openarchive.ki.se/xmlui/handle/10616/45181

The dataset is available for download with the tool Datalad (https://www.datalad.org/). The command after installing Datalad is:
datalad install -r https://github.com/NilsonneData/SleepyBrain1.git

Earlier versions of this dataset can be found here: https://openneuro.org/datasets/ds000201/versions/1.0.3

斯德哥尔摩困倦脑研究I（Stockholm Sleepy Brain Study I）是一项针对48名20~30岁年轻受试者及36名65~75岁老年健康受试者的功能性脑成像（functional brain imaging）研究，采用交叉设计，在正常睡眠与部分睡眠剥夺两种条件下对受试者开展磁共振成像扫描。本研究实施了多项实验，探究情绪模仿、疼痛共情与认知重评相关机制，同时采集了静息态功能磁共振成像（resting state functional magnetic resonance imaging, fMRI）数据。此外还获取了T1加权结构像、T2加权结构像及弥散张量成像（diffusion tensor imaging, DTI）数据。在影像扫描前一晚，研究人员通过动态多导睡眠监测（ambulatory polysomnography）对受试者进行监护，并要求其要么保持常规睡眠，要么仅睡眠3小时。受试者于次日晚间前往扫描机房。除磁共振扫描外，受试者还完成了行为测试并捐献血液样本，这些样本已存入生物样本库并用于脱氧核糖核酸（DNA）分析。受试者同时完成了多项自评量表。本研究产生的多模态数据集可用于研究假设生成、睡眠剥夺与衰老效应的独立验证，同时也可用于探究不同观测指标间的横断面关联。
研究设计与实验流程的完整描述可参见：https://openarchive.ki.se/xmlui/handle/10616/45181
该数据集可通过Datalad工具（https://www.datalad.org/）下载。安装Datalad后，可执行以下命令：datalad install -r https://github.com/NilsonneData/SleepyBrain1.git
该数据集的早期版本可在此获取：https://openneuro.org/datasets/ds000201/versions/1.0.3

搜集汇总

背景与挑战

背景概述

该数据集是斯德哥尔摩Sleepy Brain研究的一部分，包含84名年轻和老年健康参与者的多模态脑成像数据，采用交叉设计比较正常睡眠与部分睡眠剥夺后的脑功能变化。数据涵盖功能磁共振成像（fMRI）实验、结构成像、扩散张量成像（DTI）、行为测试和生物样本，旨在研究睡眠剥夺和衰老对情绪处理及社会功能的影响。