WP3299 - let-7 inhibition of ES cell reprogramming - Homo sapiens

Four transcription factors (OCT4, KLF4, SOX2, and c-MYC) reprogram adult cells into stem cells. MicroRNA let-7 is a barrier to reprogramming that inhibits LIN-41, a strong reprogramming factor that is expressed in pluripotent embryonic stem cells. LIN-41 inhibits the transcription factor EGR1, which promotes cell differentiation and is another barrier to reprogramming. (Description from Worringer et al)