RNA data of human FOP patients-derived iPSCs treated with ACVR1 R206H mutant-targeting AAVs
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE213579
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We found that both A9 (amiR-RH6) and A10 (amiR-RH7)-AAVs significantly decrease osteogenic differentiation of FOP-iPSCs. We also observed that A9 and A10-AAVs treatment changed the ratio of R206H mutant to wildtype of ACVR1 in FOP-iPSCs. To identify off-target effect of A9 or A10-AAVs, we compared RNA expression of FOP-iPSCs treated with control, A9, or A10-AAVs. Comparative gene expression profiling analysis of RNA-seq data for human iPSCs treated with control, A9, or A10-AAVs.
创建时间：
2022-12-20
