Single-cell RNA sequencing analysis of Angiotensin II-induced mouse dissecting AAA samples

Dissecting abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. Complex, complicated, and extremely heterogeneous diseases like dissecting AAAs severely limit our ability to understand it. A thorough understanding of cell types and signaling pathways associated with the initiation and progression of dissecting AAA is essential for the development of medical therapy. Single-cell RNA sequencing (scRNA-seq) was performed on the abdominal aortas from ApoE-/- mice at days 28 post-Angiotensin II-induced mouse dissecting AAAs. According to the Angiotensin II-induced dissecting AAA model described in this study, alterations in cellular subpopulations, fractions, and transcriptome profiles are present. Overall design: Examination of the transcriptomic profiles of the abdominal aortic single cells from ApoE-/- mice at days 28 post-Angiotensin II-induced mouse dissecting AAAs or normal abdominal aortas.