MicrosatNavigator: Exploring nonrandom distribution and lineage-specificity of microsatellite repeat motifs on vertebrate sex chromosomes across 186 whole genomes

Microsatellites are short tandem DNA repeats, ubiquitous in genomes. They are believed to be under selection pressure, considering their high distribution and abundance beyond chance or random accumulation. However, limited analysis of microsatellites in single taxonomic groups makes it challenging to understand their evolutionary significance across taxonomic boundaries. Despite abundant genomic information, microsatellites have been studied in limited contexts and within a few species, warranting an unbiased examination of their genome-wide distribution in distinct versus closely related-clades. Large-scale comparisons have revealed relevant trends, especially in vertebrates. Here, “MicrosatNavigator,” a new tool that allows quick and reliable investigation of perfect microsatellites in DNA sequences was developed. This tool can identify microsatellites across the entire genome sequences, considering their evolutionary variability and the simplicity of their evolutionary mechanisms. U..., , , , # MicrosatNavigator: Exploring nonrandom distribution and lineage-specificity of microsatellite repeat motifs on vertebrate sex chromosomes across 186 whole genomes

Dataset DOI: [10.5061/dryad.qz612jmm7](10.5061/dryad.qz612jmm7)

## Description of the data and file structure

The dataset contains all density and abundance data about the distribution of microsatellites in 186 whole genome sequences. Fasta sequence was collected from public databases (NCBI, DDBJ, ENA) and then processed by MicrosatNavigator. The output microsatellite data has been organized and structured in various TSV and Excel files.

## Description of the data and file structure

The dataset contains:

File S1: Supplementary_File_1_GC_Category_Python_script.zip: Python script allowing to categorize microsatellite category
File S2: Supplementary_File_2_Simulated_fasta_files.zip: Simulated FASTA dataset used for benchmark testing of MicrosatNavigator

Supplementary_table_1–14.zip:

Table S1: List of genome assemblies t...