The influence of immunization with ΔfupAΔcapB (A), ΔclpB (B) or LVS (C) on pulmonary cytokine levels following aerosol challenge with SCHU S4.

The analysis is based on lung data from day 4 and 7. The correlation between cytokine levels and bacterial load are presented in column 1. The cytokine levels were modeled using ANOVA with the bacterial load (CFU) and the immunization (Imm) as explanatory variables; their corresponding P values are presented in columns 2 and 3. Cytokines significantly affected by the vaccines are highlighted by a single asterisk. The mean effects, after removing the affect of the bacterial load, are presented in columns 4–6. P values for the pair-wise comparisons are presented in columns 7–9 and significant findings are highlighted by a double asterisk.