Bcell assay.

Results of the efficacy and cytotoxicity tests of 16 of our kinase inhibitors (‘Compound’ column) on B-cell and T-cell lines. The four type of assays are reported: ‘B-cell efficacy’, ‘T-cell efficacy’, ‘Cytotoxicity/ WST1 RPMI 1788’ and ‘Cytotoxicity/ WST-1 Jurkat’. For each assay the mean of 4 different independent measures and the standard deviation (SD) are reported. Three different indexes have been calculated: ‘Therapeutic Index (TI)/ WST1 RPMI 1788/B-cell’ (B-cell/B-cell), ‘Therapeutic Index (TI)/ WST1 Jurkat/B-cell’ (T-cell/B-cell), and ‘Selectivity Index (SI)/ MLR/B-cell’ (T-cell/B-cell). Mycophenolate Mofetyl and Cyclosporine A have been used as positive controls.
(XLSX)