Dataset for the project "Towards precision medicine in psychiatry: clinical validation of a combinatorial pharmacogenomic approach" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2016-02361697)

Dataset for the project “Towards precision medicine in psychiatry: clinical validation of a combinatorial pharmacogenomic approach” Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2016-02361697)

Aim 1: Assessment of the validity and clinical utility of a pharmacogenetic test in the selection of antidepressant treatment for patients with Major Depressive Disorder.

Aim 2: Pharmacokinetic analysis and identification of novel genetic variants linked with no response to treatment and/or with the occurrence of side effects.

Aim 3: Implementation of the combinatorial algorithm based on possible new findings.

This dataset contains :

RawData_Aim1

·         Materials and Methods for Aim 1 (Materials and methods_RawData_Aim1)

·         An Excel table (RF16 - Genotyping - Aim1) with the following sheets:

- Sheet 1: Genotyping results

- Sheet 2: Metabolizer phenotype results for CYP2D6 and CYP2C19 genes

RawData_Aim2

·         Materials and methods Sequencing_RawData_Aim2

·         Materials and methods Pharmacokinetics_RawData_Aim2

·         VCF data from sequencing analysis (filtered_variants - Aim2)

·         Pharmacokinetics analysis (Pharmacokinetics Data_Aim2)

RawData_Aim3

·        An Excel table with data from clinical assessments (Clinical Data_Aim3)