Expression data of Familial adenomatous polyposis (FAP) organoids

FAP is an autosomal-dominant inherited disease caused by germline mutations in the APC gene 1. Two major FAP phenotypes, CFAP and AFAP, can be distinguished based on polyp numbers and age of onset. CFAP is characterized by the presence of hundreds to thousands of polyps. About half of these patients develop adenomas by age 15, and 95% develop adenomas by age 35. AFAP patients exhibit a milder phenotype than CFAP patients; AFAP is characterized by fewer polyps, later adenoma onset, and lower CRC risk. We used microarrays to analyze the expression profiles of organoids established from three CFAP and two AFAP patients. Organoids were collected for RNA extraction and hybridization on Affymetrix microarrays. Each sample represents an independent organoid established from a patient. HCT number represents patient and 5 patients were analyzed in this study.