Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties I
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This study reveals supeior efficiacy of triple combination treatment (TCT) based on anti-PD-(L)1 and anti-4-1BB/OX40 and describes immunological mechanisms underlying synergism between the treatment components Using scRNA-Seq of TILs isolated from isotype- and TCT-tretaed B16-inoculated mice we defined a functional, phenotypic and developmental T cell heterogeneity within treated and non treated tumors.
创建时间：
2021-12-22
