Dual-Functionalization of Alkynes via Copper-Catalyzed Carbene/Alkyne Metathesis: A Direct Access to the 4‑Carboxyl Quinolines
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https://figshare.com/articles/dataset/Dual_Functionalization_of_Alkynes_via_Copper_Catalyzed_Carbene_Alkyne_Metathesis_A_Direct_Access_to_the_4_Carboxyl_Quinolines/2070724
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资源简介:
A copper-catalyzed novel carbene/alkyne
metathesis cascade reaction
with alkyne-tethered diazo compounds is described. The whole transformation
features a dual-functionalization of alkyne to install one CN
and one CC bond on each carbon with azide and diazo groups,
respectively, in one reaction, which represents a practical synthetic
alternative to the multisubstituted 4-carboxyl quinoline derivatives
and with most of them in high to excellent yields.
创建时间:
2016-02-04



