Translational profiling reveals that mRNAs encoding cuticle collagens are translationally repressed upon nsun-1 knockdown
收藏NIAID Data Ecosystem2026-03-12 收录
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资源简介：
By comparing mRNAs contained in the polysome fraction to total mRNAs in Caenorhabditis elegans exposed to either RNAi control or nsun-1 RNAi, we found that loss of NSUN-1 translationally represses genes associated with collagens, cuticle integrity and development. These changes explain phenotypes of nsun-1 depletion, which include impaired fecundity, gonad extrusion and reduced barrier function. 12 samples in total, three independent biological replicates, RNAi control vs. nsun-1 RNAi, total mRNAs and polysomal mRNAs for all conditions
创建时间：
2020-12-11
