Group Additivity Analysis of the Heat Capacity Changes Associated with the Dissolution into Water of Different Organic Compounds

A group additivity approach is applied to the large positive heat
capacity changes associated with the
dissolution process into water of different classes of organic
molecules. The results show that the contribution of
nonpolar CH groups is approximately constant for all the organic
molecules studied, regardless of their chemical
nature and originating phase. Further analysis leads to the
conclusion that the unique properties of water are the
main physical cause of these results.