Non‐invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near‐infrared light into the human brain through soft skin‐conforming silicone waveguides

Noninvasive delivery of near‐infrared light (IRL) to human tissues has been researched as a treatment for several acute and chronic disease conditions. We recently showed that use of specific IRL wavelengths, which inhibit the mitochondrial enzyme cytochrome c oxidase (COX), leads to robust neuroprotection in animal models of focal and global brain ischemia/reperfusion injury. These life‐threatening conditions can be caused by an ischemic stroke or cardiac arrest, respectively, two leading causes of death. To translate IRL therapy into the clinic an effective technology must be developed that allows efficient delivery of IRL to the brain while addressing potential safety concerns. Here, we introduce IRL delivery waveguides (IDWs) which meet these demands. We employ a low‐durometer silicone that comfortably conforms to the shape of the head, avoiding pressure points. Furthermore, instead of using focal IRL delivery points via fiberoptic cables, lasers, or light‐emitting diodes, the distr..., , , # Non‐invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near‐infrared light into the human brain through soft skin‐conforming silicone waveguides

[https://doi.org/10.5061/dryad.83bk3jb35](https://doi.org/10.5061/dryad.83bk3jb35)

## Description of the data and file structure

\"Figure 3\" is the average infrared light output power intensity of five infrared light delivery waveguides presented in milliwatts at different locations on the waveguide.

\"Figure 4b\" and \"Figure 4c\" are the emission uniformity profile of five infrared light delivery waveguides from proximal to distal sides (Figure 4b) or left to right sides (Figure 4c) of the waveguide. Data is presented in pixel intensity (unitless).

\"Figure 5a\" is the detected transmission of infrared output power and irradiance through intact and unfixed human cadaver heads. Light inputs were compared between the IDW (infrared light delivery waveguide) or FOC (fiberoptic cable). Data is in microwatts o...