Properties of Anticoagulants.
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a1U ≡ 170 nM functional heparin molecules; in blood, >90% of UFH may be unavailable for binding with AT [28], [45].bFpx binds almost exclusively to AT in blood [34], [46].cCtrough – Cmax (10 mg once daily): 5 – 8% free in plasma [47], [48].dDose ranges for Argatroban, a structurally related reversible thrombin inhibitor in clinical use (KD = 20 nM) [49].eCtrough – Cmax for Dabigatran (220 mg once daily), a reversible thrombin inhibitor (KD = 50 pM) [50], [51].
创建时间：
2015-12-02
