RHEUMATOID ARTHRITIS : EPIDEMIOLOGY , PATHOGENESIS , CLINICAL APPEARANCES AND MODERN TREATMENT APPROACHES

Rheumatoid arthritis (RA) — chronic , progressive , autoimmune disease mainly synovial joints hurts and of patients functional reduces the ability¹ . World The prevalence of RA is 0.5–1 % constitutes² , in women to men 2–3 times more than more common². Disease usually 30–50 years old starts between ², but younger and old also occurs in patients Pathogenesis complicated genetic predisposition , environment factors and immune system dysfunction main plays a role³ .

RA development synovial in the joints chronic inflammation , pannus formation and bone and chordates degradation take comes ⁴. Clinical in terms of patients morning joint stiffness , swelling, pain , fatigue and general anxiety feels ⁴ . Joints injury symmetrical becomes chronic inflammation organism other also affects systems shows ⁴.

Diagnostics RF and anti-CCP antibodies , erythrocyte sedimentation rate (ESR), C- reactive protein (CRP), X-ray , ultrasound and using MRI done increased ⁵. Modern treatment strategies DMARDs, biological medications , corticosteroids , physiotherapy and rehabilitation own inside takes ⁵. With this together the patient's psychological and social support life quality in improvement important importance has ⁵.

This in the article systematic literature analysis and retrospective observation methodology through RA's epidemiology , pathogenesis , clinical appearances and treatment approaches The results showed that RA patients individualized therapy and pharmacogenomics through effective management opportunity shows . Prevention measures , smoking throw and healthy life style disease development the risk noticeable at the level reduces ⁶.