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ROP55 is a repressor of host pro-inflammatory responses

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA881613
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Toxoplasma gondii evades the host immune response through the secretion of effector proteins such as rhoptries. Cas9 mediated knockout of the T. gondii rhoptry protein ROP55 results in the up-regulation of numerous genes related to the human inflammatory response and cell death. Subsequent complementation of the ROP55 knockout reverts expression of pro-inflammatory genes to levels seen in cells infected by wild type parasites.
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2022-09-17
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