Luecken Cite-seq human bone marrow 2021

Dataset published by Luecken et al. 2021 which contains data from human bone marrow measured through joint profiling of single-nucleus RNA and Antibody-Derived Tags (ADTs) using the 10X 3' Single-Cell Gene Expression kit with Feature Barcoding in combination with the BioLegend TotalSeq B Universal Human Panel v1.0. <br> <strong>File Description</strong> <em>cite_filtered.h5mu</em>: Filtered barcode by feature MuData object of concatenated donor’s raw counts from filtered barcodes. This is built from the Cell Ranger output and contains the RNA and ADT ("prot" key) data. <em>cite_raw.h5mu</em>: Unfiltered barcode by feature MuData object of concatenated donor's raw counts extracted by Cell Ranger. It contains the RNA and ADT ("prot" key) data. <br> <strong>Citation</strong> Luecken, M. D. <em>et al.</em> A sandbox for prediction and integration of DNA, RNA, and proteins in single cells. Thirty-fifth Conference on Neural Information Processing Systems Datasets and Benchmarks Track (2021). <br> <strong>Original data link</strong> https://openproblems.bio/neurips_docs/data/dataset/本数据集由Luecken等学者于2021年发布，包含人类骨髓样本的单细胞联合多组学表征数据：采用搭载特征条形码（Feature Barcoding）技术的10X 3'端单细胞基因表达试剂盒，结合BioLegend TotalSeq B 通用人类抗体面板v1.0，对单细胞核RNA与抗体衍生标签（Antibody-Derived Tags, ADTs）进行联合检测。<br><strong>文件说明</strong><br><em>cite_filtered.h5mu</em>：该文件为经过滤的条形码-特征MuData对象，整合了过滤后条形码对应的供体原始计数数据。其基于Cell Ranger的输出结果构建，包含RNA与ADT（键名为"prot"）数据。<br><em>cite_raw.h5mu</em>：该文件为未经过滤的条形码-特征MuData对象，整合了由Cell Ranger提取的供体原始计数数据，同样包含RNA与ADT（键名为"prot"）数据。<br><strong>引用信息</strong><br>Luecken, M. D. <em>et al.</em> 《单细胞内DNA、RNA与蛋白质的预测与整合沙盒》. 第三十五届神经信息处理系统大会数据集与基准赛道（2021）.<br><strong>原始数据链接</strong> https://openproblems.bio/neurips_docs/data/dataset/