Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

The liver from each mouse was collected, and samples were prepared for metabolomics analysis. The analysis was performed by Hangzhou Kaitai Biotech Co., Ltd. (Hangzhou, China). During the study explained above, two mice from each group were euthanized and sacrificed to fully understand the metabolic changes in the serum. The serum from each mouse was collected, and samples were prepared for metabolomics analysis. The analysis was performed by Shenzhen BGI Co., LTD (Shenzhen, China).