New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing β-ketoamine ligands L′ (HL′ in general; in detail, HLph,ph = (4Z)-3-methyl-4-((phenylamino)(phenyl)meth

NIAID Data Ecosystem50

Data Sheet 1_Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases.docx

可吸入纳米药物递送

NK细胞治疗

IntroductionOsteosarcoma frequently metastasizes to the lungs, significantly reducing survival in pediatric and young adult patients, with current therapies having limited efficacy. This study aimed t

NIAID Data Ecosystem00

Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis

癌细胞耐药性

磷酸化蛋白质组学信号网络

Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid,

NIAID Data Ecosystem70

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

癌细胞耐药性

靶向药物开发

This study identifies phosphorylation of SHP2 at tyrosine 62 (pY62) as a conserved mechanism of resistance to allosteric SHP2 inhibitors. By stabilizing an open, active SHP2 conformation, pY62 phenoco

DataCite Commons2026-04-10 更新30

Selection of tumor resistant variants following sustained NK-mediated immune stress

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