p53-dependent transcription in hTERT-RPE1 cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229160
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We investigated the genes that were most strongly activated by p53 in this immortalized human cell line following treatment with the MDM2 inhibitor nutlin-3a. To identify genes that were activated by p53, we comparatively analyzed parental cells and isogenic derivatives. Wild type, p53-knockout and cells harboring a heterozygous p53 A276P mutation were assessed. Comparative gene expression profiling analysis of RNA-seq data for hTERT-RPE1 cells and its derivatives (p53-/- and p53+/A276P).
创建时间：
2023-05-03
