The Original Data.

ObjectivesNucleated red blood cells (NRBCs) have been reported to correlate to poor prognosis in critically ill patients. This study aimed to identify the role of NRBC count in early diagnosis of acute kidney injury (AKI) and prediction of poor prognosis in patients with acute pancreatitis (AP).MethodsThis retrospective cohort study enrolled AP patients who were admitted to our hospital from January 1, 2020 to January 1, 2024. Demographic data, NRBC count, laboratory indicators, and outcomes were recorded. Binary logistic regression analysis was used to identify independent biomarkers for AKI diagnosis and prognosis of AP. Receiver operating characteristic (ROC) curves, net reclassification index (NRI) and integrated discrimination improvement (IDI) were used to evaluate the predictive value of NRBC count. Kaplan-Meier curves were generated to compare survival rate between different groups.ResultsA total of 486 patients with AP were included in this study. Patients with NRBCs in their peripheral blood were classified into the NRBC (+) group (n = 190), and those without NRBCs in their peripheral blood were classified into the NRBC (-) group (n = 296). Patients in the NRBC (+) group had a higher AKI incidence (29.5% vs 3.0%, p 9/L). Kaplan–Meier survival analysis demonstrated that patients with NRBC count > 0.015 × 109/L (χ² = 85.09, p ConclusionNRBC count serves as a valuable predictive biomarker for both AKI incidence and poor prognosis in patients with AP.