Crystal structure of catalytic domain of TACE with carboxylate inhibitor
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Crystal structure of catalytic domain of TACE with carboxylate inhibitor Descriptor: (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid, ADAM 17, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... Authors: Orth, P. Deposit date: 2008-10-15 Release date: 2008-11-18 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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2008-10-15
