K63polyUb-RIPK1 is deubiquitinated

K63-deubiquitination of RIP1 abolishes its ability to activate NF-kappa-B upon TNF-alpha stimulation and leads to the formation of the cytosolic caspase-8 containing complex II and subsequent apoptosis.

K63去泛素化RIP1消除了其在TNF-α刺激下激活NF-κB的能力，并导致包含细胞质caspase-8复合物II的形成，进而引发细胞凋亡。