Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity
收藏CaltechDATA2022-11-28 更新2026-04-16 收录
下载链接：
https://data.caltech.edu/doi/10.22002/ee2yc-fg857
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资源简介：
Matrix stiffening is a quintessential feature of aged tissues. Authors show that an aged (stiff) matrix epigenetically represses the gene encoding the longevity factor, α-Klotho, resulting in chondrocyte dysfunction, a leading cause of osteoarthritis.
提供机构：
University of Pittsburgh; California Institute of Technology
创建时间：
2022-11-28
