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Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity

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CaltechDATA2022-11-28 更新2026-04-16 收录
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Matrix stiffening is a quintessential feature of aged tissues. Authors show that an aged (stiff) matrix epigenetically represses the gene encoding the longevity factor, α-Klotho, resulting in chondrocyte dysfunction, a leading cause of osteoarthritis.

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2022-11-28
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