Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia [barcode-seq SG12]

耐药性机制

Targeting the MYST acetyltransferases are an exciting therapeutic opportunity in acute myeloid leukaemia (AML). Here we define the individual and combined contribution of KAT6A, KAT6B and KAT7, in ran

NIAID Data Ecosystem90

Data supporting the publication: Transcriptomic analysis of glycolytic regulation by lncRNAs in acute myeloid leukemia

急性髓系白血病

长链非编码RNA

Acute myeloid leukemia (AML), a high-mortality malignancy, limits the efficacy of traditional therapies due to high heterogeneity. Glycolysis drives AML progression via the tumor microenvironment, but

DataCite Commons2026-03-16 更新50

Supplementary Table 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

急性髓系白血病

转录因子调控

Transcription Factor Enrichment Analysis of MOLM13 Bulk RNA-Seq (24 Hours After Drug Treatment)

Figshare2023-07-05 更新40