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Loss of PD-1 aggravates plaque pathology by disrupting microglial phagocytosis in APP/PS1 mice

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NIAID Data Ecosystem2026-03-13 收录
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Astrocytic secretion of soluble B7-H1 and subsequent engagement with microglial PD-1 regulates microglial clearance of Ab by modulating the expression of CD36. Wild type and PD-1 KO mice brains at 0, 2, and 8 hours. Some treated with Amyloid-beta and some without.

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2021-12-01
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