<p>Source data and statistical results of the 1000-permutation linear correlation test under the Constrained and Lost Model.</p>

This model incorporates a filtering mechanism where a specified proportion (e.g., 30%) of the genotype combinations derived from the pathogenic combinations are “lost” or excluded across all populations. The simulation was performed using the command python convergence_loss_times_origion.py.txt 1000 20 20 30 0 1. The first sheet provides details of the first permutation, showing how the random loss of combinations in the initial population is consistently applied to others, Despite the reduction in combination elements, the results in the subsequent sheets demonstrate that the matrix-form linear correlation between genotype frequency and disease prevalence remains robust across the 1000 permutation tests. (XLSX)