The oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
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https://www.ncbi.nlm.nih.gov/sra/SRP202546
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资源简介：
We show that NRF2 activation drives hepatocellular carcinoma development in vivo. Moreover, NRF2 undergoes glucose dependent modification called glycation and requires the de-glycating enzyme FN3K to maintain NRF2' oncogenic functions. Overall design: Gene expression analysis in MYC-driven murine HCC with and without NRF2 activation. NRF2 is activated by targeting its negative regulators Keap1 or Cul3 or targeting NRF2 ETGE motif by sgRNA/Cas9 editing.
创建时间：
2019-09-23
