Are GBA–Parkinson Disease patients' good candidates for Deep Brain Stimulation? A Longitudinal Multicentric study on a Large Italian Cohort

Introduction

This database includes the raw data linked with the paper “ Are GBA–Parkinson Disease patients’ good candidates for Deep Brain Stimulation? A Longitudinal Multicentric study on a Large Italian Cohort ” published on “ Journal of Neurology, Neurosurgery, and Psychiatry ”.

In this paper, we reported data about the relationship between GBA variants and DBS long-term Aim of the study: To elucidate the impact of GBA variants on long-term DBS outcome in a large Italian cohort.

Methods

We retrospectively recruited a multicentric Italian DBS-PD cohort and assessed: 1) GBA prevalence; 2) pre-DBS clinical features; 3) outcomes of motor, cognitive and other non-motor features up to 5 years post-DBS.

Results

We included 365 PD patients, of whom 73 (20%) carried GBA variants. 5-year follow-up data were available for 173 PD, including 32 mutated subjects. GBA-PD had earlier onset and were younger at DBS than non-mutated PD (NM-PD). They also had shorter disease duration, higher occurrence of dyskinesias and orthostatic hypotension symptoms. At post-DBS, both groups showed marked motor improvement, a significant reduction of fluctuations, dyskinesias and impulsive-compulsive disorders (ICD) and low occurrence of most complications. Only cognitive scores worsened significantly faster in GBA-PD already after 3 years. Overt dementia was diagnosed in 11% NM-PD and 25% GBA-PD at 5-year follow-up