The KiNativ assay platform is based on the use of biotinylated acyl phosphates of ATP or ADP that act as probes by reacting with protein kinases on conserved lysine residues in the ATP binding pocket
This dataset contains supporting data for "Synthetic lethal interaction of SHOC2 depletion with MEK inhibition in RAS-driven cancers", Cell Reports (2019).Contents:genomewide.chip: Alignment file for
APS-2-79 compound was purchased from MedChemExpress (Monmoutyh Junction, NJ, USA). The 20 mg/ml stock solution was prepared in DMSO. To calculate the IC50, JURKAT and ALL-SIL cells were cultured for 7
Pulmonary hypertension (PH) and cancer pathophysiology share common signal transduction pathways leading to abnormal endothelial and smooth muscle cell interactions and angioproliferative vasculopathy
