Single-cell dissection of multiomics changes and epigenetic regulations in human high-grade serous ovarian cancer

To systematically characterize the underlying pathological mechanisms and intratumor heterogeneity in human high-grade serous ovarian cancer (HGSC), we profiled normal fallopian tubes (FTs), primary tumors, and matched metastases to unveil the molecular characteristics associated with tumor development. After stringent quality controls, we obtained single-cell transcriptomes for a total of 5,329 cells from 61 specimens of 16 ovarian cancer patients and 6 individuals without fallopian tube malignancy as controls. We found that the genes associated with interferon (IFN) signaling, metallothioneins, and metabolism were commonly upregulated in ovarian cancer cells. In summary, our study provides valuable resources for identifying new molecular mechanisms and potential therapeutic targets for HGSC. Single cell profiles of ovarian patients **RAW DATA not provided due to Chinese laws**