Targeting the epigenetic regulation of Hedgehog transcriptional output through BET bromodomain inhibition
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58185
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资源简介：
Comparison of gene expression changes in Ptch-deficient mouse medulloblastoma cell line SmoWT-MB upon treatment with SMOi GDC-0449 or BETi JQ1. The hypothesis is that they can both inhibit the expressions of Hh signaling target genes in this Hh-driven tumor cell line. Total RNA from JQ1 or GDC-0449 treated SmoWT-MB cells in comparison with DMSO treated cells
创建时间：
2014-09-03
