Date of isolation and resistance pattern of the different isolates of M. tuberculosis as tested in the BACTEC 460 system and antibiotic resistance mutations identified in isolates obtained from eight different time points.

a: S = Susceptible, R = Resistant.wt = wild-type.b: Streptomycin-resistant isolates with wild-type rpsL were checked for mutation in rrs. The A513C mutation in rrs confers streptomycin resistance whereas the A1400G mutation confers amikacin resistance.