X-ray co-crystal structure of compound 27 in with complex JAK2
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X-ray co-crystal structure of compound 27 in with complex JAK2 Descriptor: 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol, Tyrosine-protein kinase JAK2 Authors: Miller, S.T, Ellis, D.A. Deposit date: 2023-02-20 Release date: 2023-06-21 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J.Med.Chem., 66, 2023
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2023-02-20
