Mapping and quantifying transcriptomes of MTSS1 overexpressed in the wild type nasopharyngeal carcinoma cells by RNA-Seq

Metastasis suppressor 1 (MTSS1) is frequently lost in metastatic tissues, which correlates with advanced tumor stages and poor patient prognosis across a variety of cancers. The anti-metastatic mechanisms of MTSS1 are not well understood. We applied RNAseq technology to map the transcriptomes of wild type and MTSS1 overexpressed nasopharyngeal carcinoma cells. Comparisons of the gene expression between the Myc-tagged empty vector and Myc-MTSS1 samples were carried out to determine the differentially regulated genes.