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RNA-Seq analysis of Rpl22l1-deficient murine CD4-CD-CD44-CD25+ (DN3) thymocytes

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE183054
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Rpl22l1 is a highly conserved ribosomal protein paralog that plays a regulatory role in certain hematopoietic cell lineages. Rpl22l1-deficiency arrests the development of T cells at the DN3 stage. RNA-seq analysis was performed to identify the molecular basis for the arrest Adult DN3 thymocytes were isolated from Vav-Cre- Rpl22l1fl/fl (L1 KO) and Vav-Cre+ Rpl22l1fl/fl mice (WT). Triplicate samples were lysed in Trizol. Total RNA was isolated and processed as previously described (Miyazaki et al., 2017).
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2022-03-02
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