Crystal structure of SARS-CoV-2 Mpro with AB-343.

Crystal structure of SARS-CoV-2 Mpro with AB-343. Descriptor: (1S,3S,4S)-N-[(2S)-1-azanylidene-3-[(3S)-5,5-dimethyl-2-oxidanylidene-pyrrolidin-3-yl]propan-2-yl]-2-[(2R)-3-cyclobutyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]propanoyl]-5,5-bis(fluoranyl)-2-azabicyclo[2.2.2]octane-3-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... Authors: Prasad, A, Blaesse, M, Maskos, K, Steinbacher, S, Konz Makino, D.L. Deposit date: 2024-08-28 Release date: 2024-12-04 Last modified: 2024-12-11 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Biological characterization of AB-343, a novel and potent SARS-CoV-2 M pro inhibitor with pan-coronavirus activity. Antiviral Res., 232, 2024