A comparison of the general WHO guidelines with the possible recommendations for the study area, based on threshold analysis.

x = diseased; 1-x = not diseased; Tc = Treatment cost; Tmort = mortality caused by the treatment; Lv = value of a death averted; Dmort = Disease mortality; t = test threshold; tT test/treatment threshold; tc = test cost; FP = false positive rate; TP = true positive rate; FN = false negative rate; TN = true negative rate; Tb = Treatment burden ( = Tc +Tmort * Lv); Db = Disease burden ( = Dmort * Lv).Tc = Treatment cost; Tmort = mortality caused by the treatment; Lv = value of a death averted; Dmort = Disease mortality; t = test threshold; tT test/treatment threshold; tc = test cost; FP = false positive rate; TP = true positive rate; FN = false negative rate; TN = true negative rate; Tb = Treatment burden ( = Tc +Tmort * Lv); Db = Disease burden ( = Dmort * Lv).