Hyperosmolarity inhibits secretion of archetypal cytokines induced by TNFα or IL-1β.

Hyperosmolar effects (400 mOsms, by either NaCl or sorbitol), on 27 inflammation-related gene products secreted by stimulated A549 cells measured by multiplex assay. Chosen from genes clustered on chromosomes 2, 4, 5 and 17 and eight others. Fold increases and inhibition were compiled from three separate experiments. Stimulated responses are bolded, if these measured over 100 ng/ml except for IL-4 (less than 20 ng/ml) and at least >5 fold. >400, >100, >5 The effect of HTS and Sorbitol (both 400 mOsm) are shown as % response of stimulated values and also underlined if these are at least 33% different, >75, >50, >33. NA, not applicable, – indicates undetectable.Hyperosmolarity inhibits secretion of archetypal cytokines induced by TNFα or IL-1β.