Transcriptomic analysis of pulmonary vein under pathological pulmonary vein stenosis

We reported the RNAseq analyses of pulmonary vein tissues at the age of postnatal day 21 (P21) on SD rats with or without pulmonary vein stenosis. Pulmonary vein stenosis was induced by performing pulmonary vein banding surgery within 24 hours postnatally. RNAseq analyses of the pulmonary vein tissues was generated at P21 from 3 sham-operated rats and 3 pulmonary vein banding rats. The results revealed that there were 1124 differentially expressed genes between PAB and sham group at P7, among which 714 were upregulated and 410 were downregulated.本研究报道了出生后第21天（P21）的SD大鼠（Sprague Dawley大鼠）肺静脉组织的RNA测序（RNA sequencing，RNAseq）分析结果，实验大鼠分为存在肺静脉狭窄与无肺静脉狭窄两类。肺静脉狭窄模型通过在大鼠出生后24小时内实施肺静脉环扎手术构建。本研究采集3只假手术大鼠与3只肺静脉环扎大鼠在P21时期的肺静脉组织开展RNAseq分析。分析结果显示，在出生后第7天（P7），肺静脉环扎组与假手术组间存在1124个差异表达基因，其中714个基因表达上调，410个基因表达下调。